I've just tried PlayOnLinux 4.3.4 on two machines---a Desktop running Ubuntu 20.04 and an old laptop running the Raspberry Pi Desktop (for intel chips, it's based on Debian 10.)
Acrobat Reader runs almost without problems, but when it is closed a generic PlayOnLinux Wizard error dialog box opens and it has to be manually closed (or cancel or next clicked).
The only problem I found so far is that Acrobat Reader runs and opens and displays pdf files correctly, but the dialogs for Preferences and Document Properties open without any text displayed.
I realized this post is in the wrong section. I'll repost over at Supported Apps.