I prefer PlayOnLinux over Lutris any day!
Looks like they have stepped up and patched Wine 1.21 to fix the Fallout 4 intro dsound bug. So now they have an installer.
https://lutris.net/games/fallout-4/
I hope PlayOnLinux can get a patched version of Wine so we can play Fallout 4 as well.
Edited by booman