I've gotten three versions of Hearts of Iron (1, 2 and Arsenal of Democracy) working under POL. This is a grand strategy game covering the period from 1936 up to 1947 or the 1960s depending on version.
Platform: Ubuntu 16.04 on Intel. Dell 22" monitor at 1920x1080.
POL version: 4.2.12 with python 2.7.12
Wine version: 1.4 or 1.5 32 bit. They don't seem to work properly with anything later. YMMV
Configuration details: none at all. Just install and run.
They are working about as well as they did under windows. All features functional. You might need to alt-tab out of and back into the game so it runs full-screen on a large monitor. The game has no resolution controls, but POL seems to take care of it.