I agree. This is the BIG question I have but nobody knows the answer.
I think we are in such a niche world. Linux (1%). Then Wine on Mac (1% of 1%). I'm sure some dude is running the alt keys on his mac with no problem. But he is probably too busy to share his knowhow with the web.
Still Im stuck with a broken Excel 2010 installation because I cant use the alt key properly.
I noticed that PlayOnMac / Wine, remaps the Command Key to the Alt Key in Wine. However, I cannot press and hold the alt key. It seems like they have put it to rapid fire. Extremely annoying stuff.