Hey, I have the same problem
Windows 10 Home/ 16299.19 / 1709
GTX 1070 (388.13) / Intel i5 4670k
I use Spotify desktop version, becomes unresponsive after launching fullscreen game such as Overwatch or Nioh. Steam also suffers from this problem https://omegle.onl/ .
Dual monitor set up, 2x 1920x108
Aangepast door hisen22