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Whenever I try to install Guild Wars 2, the arch in playonlinux.cfg is set to amd64 (instead of x86 like it is for all my other games - I am running on Intel). If I manually edit the config file, and select an x86 version of wine to use, it crashes immediately. It seems like something else in the system still thinks it's amd64 and the mismatch is causing problems.

[code language=playonlinux]
POL_System_SetArch "auto"
[/code]
means use 32bit Wine on 32bit architectures and 64bit Wine on 64bit architecture, so the script does select 64bit Wine if your architecture is 64bit.
You [b]cannot[/b] change the architecture of a Wine virtual drive afterward, that's a limitation of Wine.
You could force a 32bit virtual drive by taking a copy of the script, removing above instruction, and use it to reinstall (after removing existing virtual drive manually)
Still, the question we avoided so far is... Why?

Edit: Oooooh I understand, you're being confused by "amd64" for an Intel CPU.
That's fine, that's the name of the 64bit architecture most commonly used (It's also sometimes called x86-64), even with Intel CPUs.
Intel also developed its own architecture (IA-64), but it's only used on some servers I think.

See

Edited by petch

Thanks for the info! I've got it all sorted now.