Are you saying you are trying to run an application without installing it first? If that is what you mean I don't think that will work besides POL uses wine directly and from what I'm aware of you need to install first before running an application.
You can run specific exe in any created wineprefix. With the configure panel, select a wineprefix (one that can be compatible or create one with a specific wine version), go on the last tab and you can use "run a exe in that wineprefix"
Gentils modérateur dans mes bon jours - Attention, à tenir hors de portée des enfants. En cas de contact, veuillez immédiatement rincer à l'eau clair. Peut provoquer des sueurs froide !